Robust, high-throughput protocol for deriving microglia from human stem cells reported
"NYSCF's mission is to bring cures to patients faster," said Susan L. Solomon, CEO and co- founder of NYSCF. "One way we work towards this goal is by developing methods and models that lift the entire field of stem cell research. This new protocol is the perfect example of the type of method that will enable researchers around the world to accelerate their work." Published in Stem Cell Reports , this microglia protocol is optimized for use in high-throughput experiments, such as drug screening and toxicity testing among other large-scale research applications, and has the benefit of allowing such experiments to be carried out on multiple patient samples. The scientists determined that the protocol is robust and reproducible, generating microglia from sixteen induced pluripotent stem (iPS) cell lines, stem cells that are created from individual patients. Microglia from humans have long been a desired research model, but are difficult to obtain for laborat...